Postdoctoral publications:


A. Urbanaitė, L. Šteinys, A. Brukštus, I. Čikotienė; Addition of Primary Amines to 2-(1-Alkynyl)-2-cycloalken-1-ones, Eur. J. Org. Chem., 2017, DOI: 10.1002/ejoc.201700119.
E. Kazlauskas, A. Brukštus, H. Petrikas, V. Petrikaitė, I. Čikotienė, D. Matulis; Improving the Hsp90 Inhibitors Containing 4-(2,4-Dihydroxyphenyl)-1,2,3-thiadiazole Scaffold: Synthesis, Affinity and Effect on Cancer Cells, Anticancer Agents Med. Chem., 2017, accepted.
M. Jonušis, L. Šteinys, R. Bukšnaitienė, I. Čikotienė; Synthesis of Alkoxymethyl Groups Containing Isoxazoles and Chromones, Synthesis, 2017, 49, 1122 – 1130.
A. Urbanaitė, I. Čikotienė; Synthesis of Polysubstituted Pyrroles through the Tandem 1,3-Addition-5-Endo-Dig Cyclization of 1-(1-Alkynyl)Cyclopropyl Imines, Eur. J. Org. Chem., 2016, 5294 – 5300.
A. Urbanaitė, M. Jonušis, R. Bukšnaitienė, S. Balkaitis, I. Čikotienė; Electrophile-mediated Reactions of Functionalized Propargylic Substrates, Eur. J. Org. Chem., 2015, 7091 – 7113.
I. Karpavičienė, G. Valiulienė, V. Raškevičius, I. Lebedytė, A. Brukštus, V. Kairys, R. Navakauskienė, I. Čikotienė; Synthesis and Antiproliferative Activity of α-Branched α,β-Unsaturated Ketones in Human Hematological and Solid Cancer Cell Lines, Eur. J. Med. Chem., 2015, 98, 30 – 48.
R. Bukšnaitienė, I. Čikotienė; Electrophile-Promoted Cyclization of Propargylic Amides, Synlett, 2015, 26, 479 – 483.
R. Bukšnaitienė, A. Urbanaitė, I. Čikotienė; Formation of Condensed 1H-Pyrrol-2-ylphosphonates and 1,2-Dihydropyridin-2-ylphosphonates via the Kabachnik-Fields Reaction of Acetylenic Aldehydes and Subsequent 5-Exo-dig or 6-Endo-dig Cyclizations, J. Org. Chem., 2014, 79, 6532 – 6553.
I. Čikotienė; Rearrangements of Propargylic Esters can be Induced by Some Electrophiles, Org. Lett., 2014, 16, 2260 – 2263.
C. Trujillo, G. Sánchez-Sanz, I. Karpavičienė, U. Jahn, I. Čikotienė, L. Rulíšek; Divergent Pathways and Competitive Mechanisms of Metathesis Reactions between 3-Arylprop-2-inyl esters and Aldehydes: An Experimental and Theoretical Study, Chem. Eur. J., 2014, 20, 10360 – 10370.
L. Labanauskas, R. Mazeikaite, G. Urbelis, O. Gedrimaite, J.Sudzius, I. Cikotiene; Synthesis of 1-substituted-4-[4-(1H-indol-3-yl)butyl]piperazines, ARKIVOC, 2013, (iv) 363-376.
I. Karpaviciene, I. Cikotiene, J. M. Padron; Synthesis and antiproliferative activity of α-branched α,β-unsaturated ketones, Eur. J. Med. Chem., 2013, 70, 568 – 578.
I. Cikotiene, M. Jonusis, V. Jakubkiene; The first example of the Fischer–Hepp type rearrangement in pyrimidines, Beilstein J. Org. Chem., 2013, 9, 1819 – 1825.
I. Karpaviciene, I. Cikotiene, A Unique Cascade Reaction between 3-Arylprop-2-inylcarboxylates and Benzaldehydes Leading to the Formation of Morita–Baylis–Hillman Adducts, Org. Lett., 201315 (1), 224 – 227.
V. Jakubkiene, J. Zurba, I. CikotieneN-Nitroso Moiety Assisted Nucleophilic Aromatic Substitution of 6-Chloropyrimidines: A Facile and Efficient Synthesis of 4,6- and 2,4-Pyrimidinediamines, Synthesis, 2013, 45 (4), 448 – 451.
 I. Cikotiene, R. Buksnaitiene, Study on the Reactions of Acetylenic Aldehydes with Dimethylphosphite in Basic Media: Phosphonate – Phosphate Rearrangement versus 5-exo-dig Cyclization Reactions, Adv. Synth. Catal. 2012, 354, 2719 – 2726.
Swee Y. Sharp, S. Mark Roe, Egidijus Kazlauskas, Inga Cikotiene, Paul Workman, Daumantas Matulis, Chrisostomos Prodromou, Co-Crystalization and In Vitro Biological Characterization of 5-Aryl-4-(5-Substituted-2-4-Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors, PlosOne, 2012, 7 (9), e44642.
I. Cikotiene, Intramolecular Iodine-Mediated Oxygen Transfer from Nitro Groups to C≡C Bonds, Eur. J. Org. Chem., 20122766 – 2773.
R. Buksnaitiene, I. Cikotiene, A facile and efficient synthesis of 1-trichloromethyl-1,2-dihydrobenzo[b][1,6]naphthyridines via three-component reaction among 2-alkynylquinoline-3-carbaldehydes, primary amines, and chloroform, Heterocycl. Commun, 2012, 18, 87 – 92.
V. Jakubkiene, I. Cikotiene, Effect of substituent structure on pyrimidine electrophilic substitution: A Rebuttal, Tetrahedron, 2012, 68, 2294 – 2298.
I. Karpaviciene, R. Lapinskaite, A. Brukstus, I. Cikotiene, Reductive Ring Cleavage of Nonconjugated Δ2-Isoxazolines to β-Hydroxy Ketones with Aluminum and Copper (II) Chloride, Synlett, 2012, 23, 381-384.
EU patent: D. Matulis, Cikotiene I., Kazlauskas E., Matuliene J. “5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof.” EP 2268626 B1. 2012-02-01.
USA patent: Matulis D., Cikotiene I., Kazlauskas E., Matuliene J. 5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof. US 831413220. 2012-12-20.
C. Ríos-Luci , R. Domínguez-Kelly, L. G. León, E. Díaz-Rodríguez, R. Freire, A. Pandiella, I. Cikotiene, J. M. Padrón, A modular mechanistic approach to trim cellular targets in anticancer drug discovery, Bioorg. Med. Chem. Lett, 2011, 21, 6641 – 6645.
R. Buksnaitiene, I. Cikotiene, Novel Synthetic Method of 2-(2-Oxoethyl)-1H-indole-3-carbaldehydes, Synlett, 2011, 2529 – 2532.
I. Žutautaitė, A. Brukštus, I. Čikotienė, Synthesis of 4,4-dialkyl-3,4-dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amines, Chemija, 2011, 22, 138 – 142.
I. Cikotiene, R. Buksnaitiene, R. Sazinas, Rapid Access to Benzo-annelated Heterocycles, Naphthalenes and Polysubstituted Benzenes through a Novel Benzannulation Reaction, Tetrahedron, 2011, 67, 706 – 717.
I. Cikotiene, R. Sazinas, R. Mazeikaite, L. Labanauskas, Unexpected Regioselectivity in Cycloisomerization of 2-Alkynyl-3- nitrothiophenes, Synlett, 2010, 3027 – 3030. Highlighted by Synfacts, 2011, 2, 140.
I. Cikotiene, E. Pudziuvelyte, A. Brukstus, Efficient One-Pot Synthesis of 6-Arylpyrrolo[3,2-d]pyrimidines from 6-Arylethynyl-5-nitropyrimidines, Synlett, 2010, 1107 – 1109.
S. Rudys, C. Ríos-Luci, E. Pérez-Roth, I. Cikotiene, J. M. Padrón, Antiproliferative Activity of Novel Benzo[b][1,6]naphthyridines
in Human Solid Tumor Cell Lines, Bioorg.Med. Chem. Lett, 2010, 20, 1504 – 1506.
I. Cikotiene, R. Buksnaitiene, S. Rudys, M. Morkunas, D. Motiejaitis, Tandem reactions of 6-phenylethynylpyrimidine-5-carbaldehydes with alcohols: regioselective synthesis of 5-alkoxy-(7Z)-7-benzylidene-5,7dihydrofuro[3,4-d]pyrimidines and 5-alkoxy-7-phenyl-5H-pyrano[4,3-d]pyrimidines, Tetrahedron, 2010, 66, 251 – 258.
E. Pudziuvelyte, C. Ríos-Luci, L. G. León, I. Cikotiene and J. M.Padrón, Synthesis and Antiproliferative Activity of 2,4-Disubstituted 6-Aryl-7H-pyrrolo[3,2-d]pyrimidin-7-one 5-Oxides, Bioorg. Med. Chem., 2009, 17, 4955 – 4960.
I. Cikotiene, V. Kairys, R. Buksnaitiene, M. Morkunas, S. Rudys, A. Brukstus, M. X. Fernandes, Study on the cyclization of 6-arylethynylpyrimidine-5-carbaldehydes with tert-butylamine: microwave versus thermal preparation of pyrido[4,3-d]pyrimidines, Tetrahedron, 2009, 65, 5752 – 5759.
I. Cikotiene, A novel and simple benzannulation reaction using the potassium salt of methyl mercaptoacetate for the synthesis of 3-aryl-2-methoxycarbonylacridines, Tetrahedron Lett., 2009, 50, 2570 – 2572.
I. Cikotiene, E. Kazlauskas, J. Matuliene, V. Michailoviene, J. Torresan, J. Jachno, D. Matulis, 5-Aryl-4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone, Bioorg. Med. Chem. Lett, 2009, 19, 1089– 1092.
I. Cikotiene, M. Morkunas, The First and Efficient Synthesis of 7-Aryl-6-methoxycarbonylquinazolines via Unexpected Reaction of 6-Arylethynylpyrimidine-5-carbaldehydes and Methyl Mercaptoacetate, Synlett, 2009, 2, 284 – 286.
S. Rudys, I. Cikotiene; Facile synthesis of 3-aryl-4-iodobenzo[b][1,6]naphtyridines, Chem. Heterocycl. Comp., 2008, 44, 1416 – 1417.
I. Cikotiene, M. Morkunas, S. Rudys, R. Buksnaitiene, A. Brukstus; An Efficient One-Pot Synthetic Method of 2,4-Disubstituted 7-Arylpyrido[4,3-d]pyrimidines from 2,4-Disubstituted 6-Arylethynylpyrimidine-5-carbaldehydes and tert-Butylamine, Synlett, 2008, 18, 2799 – 2802. Highlighted by Synfacts, 2009, 1, 16.
I. Cikotiene, E. Pudziuvelyte, A. Brukstus; Synthesis of 2,4-Disubstituted 6-Phenyl-7H-pyrrolo[3,2-d]pyrimidin-7-one 5-Oxides, J. Heterocycl. Chem., 2008, 45, 1615 – 1620.
I. Cikotiene, M. Morkunas, D. Motiejaitis, S. Rudys, A. Brukstus; The First Tandem Acetalization/5-Exodig Cyclization of 6-Phenylethynylpyrimidine-5-carbaldehydes: Efficient Synthesis of 5-Alkoxy-(7Z)-7-benzylidene-5,7dihydrofuro[3,4-d]pyrimidines, Synlett, 2008, 11, 1693 – 1697.
I. Cikotiene, E. Pudziuvelyte, A. Brukstus; Unexpected reactions of 4-amino-2-methylsulfonyl-5-nitro-6-phenylethynylpyrimidine with nucleophiles, Chem. Heterocycl. Comp., 2008, 44, 762 – 764.
I. Cikotiene, E. Pudziuvelyte, A. Brukstus, S. Tumkevicius; Study on the Reactions of 4-Amino-5-nitro-6-phenylethynylpyrimidines with Amines and Thiols, Tetrahedron, 2007, 63 (34), p. 8145 – 8150.
I. Cikotiene, R. Buksnaitiene, A. Brukstus; Synthesis of new 4-amino-7-phenylpyrido[4,3-d]pyrimidine-6-oxides, Chem. Heterocycl. Comp., 2007, 43, 515 – 516.